PileLine: a toolbox to handle genome position information in next-generation sequencing studies |
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| Authors: | Daniel Glez-Peña Gonzalo Gómez-López Miguel Reboiro-Jato Florentino Fdez-Riverola David G Pisano |
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| Affiliation: | (1) Higher Technical School of Computer Engineering, University of Vigo, Ourense, Spain;(2) Bioinformatics Unit (UBio), Structural Biology and Biocomputing Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain |
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| Abstract: | Background Genomic position (GP) files currently used in next-generation sequencing (NGS) studies are always difficult to manipulate due to their huge size and the lack of appropriate tools to properly manage them. The structure of these flat files is based on representing one line per position that has been covered by at least one aligned read, imposing significant restrictions from a computational performance perspective. |
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