Restoration of dysgenic murine (mdg) myotube contraction after addition of Schwann cells from normal mice in vitro |
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| Authors: | P Courbin A Do Thi A Ressouches C Dussartre J A Powell J Koenig |
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| Institution: | Laboratoire de Neurobiologie cellulaire, Université de Bordeaux II, URA-CNRS #1126, Talence, France. |
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| Abstract: | Muscular dysgenesis in mutant mice is characterised by failure of excitation-contraction (E-C) coupling and consequent loss of skeletal muscle contraction. Contractile activity is restored in vitro by the addition of normal mice cells (11) (18) (7). In the present study we show a new model: contraction and ultrastructural organization of dysgenic myotubes are restored by coculture with Schwann cells from normal mice. |
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| Keywords: | muscular dysgenesis E-C coupling Schwann cells |
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