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Camphor sulfonamide derivatives as novel,potent and selective CXCR3 antagonists |
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| Authors: | Yonghui Wang Jakob Busch-Petersen Feng Wang Terence J. Kiesow Todd L. Graybill Jian Jin Zheng Yang James J. Foley Gerald E. Hunsberger Dulcie B. Schmidt Henry M. Sarau Elizabeth A. Capper-Spudich Zining Wu Laura S. Fisher Michael S. McQueney Ralph A. Rivero Katherine L. Widdowson |
| Affiliation: | 1. Center of Excellence for Drug Discovery, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA;2. Molecular Discovery Research, GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, PA 19426, USA;3. Center of Excellence for Drug Discovery, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA 19406, USA |
| Abstract: | A series of N-arylpiperazine camphor sulfonamides was discovered as novel CXCR3 antagonists. The synthesis, structure–activity relationships, and optimization of the initial hit that resulted in the identification of potent and selective CXCR3 antagonists are described. |
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