2,6,9-Trisubstituted purine derivatives as protein A mimetics for the treatment of autoimmune diseases |
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Authors: | Boulos Zacharie Daniel Fortin Nicole Wilb Jean-François Bienvenu Michel Asselin Brigitte Grouix Christopher Penney |
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Institution: | ProMetic BioSciences Inc., 500 Boulevard Cartier Ouest, Bureau 150, Laval, Que., Canada H7V 5B7 |
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Abstract: | A series of 9-substituted and 2,9-disubstituted 6-(3-aminophenylamino) purines were synthesized and evaluated for their ability to mimic protein A binding to human IgG antibody. The structure–activity relationship (SAR) demonstrates that the 6-(3-aminoanilinyl) purine component was essential for activity. Purine 14 demonstrated significant activity, compared to protein A. These compounds may prove useful for the treatment of autoimmune diseases. |
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