Antioxidant and antiradical activities of resorcinarene tetranitroxides |
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| Authors: | Andriy I. Vovk Alexander M. Shivanyuk Roman V. Bugas Oxana V. Muzychka Andriy K. Melnyk |
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| Affiliation: | 1. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Murmanska, 1, 02660 Kyiv-94, Ukraine;2. ChemBio Center, Kyiv National Taras Shevchenko University, Kyiv, Ukraine |
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| Abstract: | Resorcinarene oxazines bearing four TEMPO fragments at the wide rim of the macrocycle were prepared through the aminomethylation of resorcinarene octols with 4-amino-TEMPO and formaldehyde. Tetra-TEMPO resorcinarenes are efficient scavengers of 1,1-diphenyl-2-picrylhydrazyl radicals. The model studies revealed that macrocyclic structure and intramolecular hydrogen bonding make considerable contribution to antiradical activity of these compounds. Tetra-TEMPO resorcinarenes show also superoxide dismutase-like activity and efficiently inhibit ABAP-induced peroxidation of linoleic acid. |
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