Synthesis of yashabushidiol and its analogues and their cytotoxic activity against cancer cell lines |
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| Authors: | M Narasimhulu T Srikanth Reddy K Chinni Mahesh A Sai Krishna J Venkateswara Rao Y Venkateswarlu |
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| Institution: | 1. Organic Division-I, Natural Products Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India;2. Toxicology Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A total synthesis of yashabushidiol (1a), a linear diarylheptanoid having 1,3- diol system and its analogues has been achieved by alkynylation of 3-hydroxy-5-phenyl pentanal with substituted phenyl acetylenes. All the compounds have shown significant anti-proliferative activity on human leukemia (THP-1, U-937) and melanoma (A-375) cell lines. Compounds 2a and 2b were found to be most potent with an IC50 of 12.82 μg/mL and 12.62 μg/mL, respectively, on THP-1 leukemia cell line. |
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