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4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors |
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| Authors: | John Liddle Paul Bamborough Michael D Barker Sebastien Campos Rick PC Cousins Geoffrey J Cutler Heather Hobbs Duncan S Holmes Chris Ioannou Geoff W Mellor Mary A Morse Jeremy J Payne John M Pritchard Kathryn J Smith Daniel T Tape Caroline Whitworth Richard A Williamson |
| Institution: | 1. GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, UK;2. GlaxoSmithKline R&D, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK |
| Abstract: | The synthesis and SAR of a novel series of IKK2 inhibitors are described. Modification around the hinge binding region of the 7-azaindole led to a series of potent and selective inhibitors with good cellular activity. |
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