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Discovery of 4-azaindoles as novel inhibitors of c-Met kinase |
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| Authors: | John Porter Simon Lumb Richard J. Franklin Jose M. Gascon-Simorte Mark Calmiano Kelly Le Riche Bénédicte Lallemand Jean Keyaerts Helen Edwards Alison Maloney Jean Delgado Lloyd King Anne Foley Fabien Lecomte James Reuberson Christoph Meier Mark Batchelor |
| Affiliation: | 1. UCB Celltech, 216 Bath Road, Slough SL1 3WE, United Kingdom;2. UCB Pharma, R&D, Chemistry, Chemin du Foriest, B-1420 Braine-l’Alleud, Belgium |
| Abstract: | A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development are discussed. |
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