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Carrier PNA for shRNA delivery into cells |
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| Authors: | Mizuki Kitamatsu Takanori Kubo Rino Matsuzaki Tamaki Endoh Takashi Ohtsuki Masahiko Sisido |
| Affiliation: | 1. Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, 3-1-1 Tsushimanaka, Okayama 700-0082, Japan;2. Faculty of Pharmacy, Yasuda Women’s University, 6-13-1 Yasuhigashi, Asaminami, Hiroshima 731-0153, Japan |
| Abstract: | A peptide nucleic acid (PNA)-cell-penetrating peptide (CPP) conjugate (carrier PNA) was used as ‘bridge-builder’ to connect a CPP with an shRNA. The carrier PNA successfully formed a hybrid with an shRNA bearing complementary dangling bases and the shRNA was introduced into cells by the carrier PNA, and RNAi was induced by the shRNA. |
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