Cytotoxicity of cardenolides and cardenolide glycosides from Asclepias curassavica |
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Authors: | Jun-Zhu Li Chen Qing Chang-Xiang Chen Xiao-Jiang Hao Hai-Yang Liu |
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Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China;2. Yunnan Key Laboratory of Pharmacology for Natural Products Research, Kunming Medical College, Kunming 650031, PR China |
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Abstract: | A new cardenolide, 12β,14β-dihydroxy-3β,19-epoxy-3α-methoxy-5α-card-20(22)-enolide (6), and a new doubly linked cardenolide glycoside, 12β-hydroxycalotropin (13), together with eleven known compounds, coroglaucigenin (1), 12β-hydroxycoroglaucigenin (2), calotropagenin (3), desglucouzarin (4), 6′-O-feruloyl-desglucouzarin (5), calotropin (7), uscharidin (8), asclepin (9), 16α-hydroxyasclepin (10), 16α-acetoxycalotropin (11), and 16α-acetoxyasclepin (12), were isolated from the aerial part of ornamental milkweed, Asclepias curassavica and chemically elucidated through spectral analyses. All the isolates were evaluated for their cytotoxic activity against HepG2 and Raji cell lines. The results showed that asclepin (9) had the strongest cytotoxic activity with an IC50 value of 0.02 μM against the two cancer cell lines and the new compound 13 had significant cytotoxic activity with IC50 values of 0.69 and 1.46 μM, respectively. |
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