Two new cytotoxic diterpenes from the rhizomes of Hedychium spicatum |
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| Authors: | P Prabhakar Reddy R Ranga Rao K Rekha K Suresh Babu J Shashidhar G Shashikiran V Vijaya Lakshmi J Madhusudana Rao |
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| Institution: | 1. Natural Products Laboratory, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 607, India;2. Biochemistry Division, National Institute of Nutrition, Tarnaka, Hyderabad 500 607, India |
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| Abstract: | Phytochemical investigation of CHCl3 extract of the rhizomes of Hedychium spicatum led to the isolation of two new labdane-type diterpenes, compounds 1 and 2 along with five known compounds (3–7). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. In addition, all the isolates were tested for their cytotoxicity against the Colo-205 (Colo-cancer), A-431 (skin cancer), MCF-7 (breast cancer), A-549 (lung cancer) and Chinese hamster ovary cells (CHO). Two new compounds 1 and 2 were shown good cytotoxic activity. |
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