Evaluation of synthetic sphingolipid analogs as ligands for peroxisome proliferator-activated receptors |
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| Authors: | Kiyomi Tsuji Shigeru Satoh Susumu Mitsutake Itsuo Murakami Jeong-Ju Park Qian Li Young-Tae Chang Sung-Kee Chung Yasuyuki Igarashi |
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| Institution: | 1. Laboratory of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science, Hokkaido University, Nishi 11, Kita 21, Kita-ku, Sapporo 001-0021, Japan;2. Department of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea;3. Department of Chemistry, New York University, New York, NY 10003, USA;4. National University of Singapore, Singapore 117543, Singapore |
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| Abstract: | In this Letter, we assessed newly synthesized sphingolipid analogs as ligands for peroxisome proliferator-activated receptor (PPAR)α, PPARβ or PPARγ, using a dual-luciferase reporter system. We tested 640 sphingolipid analogs for ligand activity. As a result, seven types: A9, B9, C9, C50, F66, G66 and H66, were found to show agonistic activities for PPARs. |
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