Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents |
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| Authors: | Shinnosuke Hosoda Hiroshi Aoyama Yukinori Goto Mohammed TA Salim Mika Okamoto Mariko Hashimoto Masanori Baba Yuichi Hashimoto |
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| Institution: | 1. Institute of Molecular & Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan;2. Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan |
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| Abstract: | Based on antiviral screening of our diphenylmethane derivatives prepared as steroid substitutes, we identified a 1,1-diphenylcyclobutane analog (9) and two diethyldiphenylsilane analogs (12 and 13) as superior lead compounds with potent anti-bovine viral diarrhea virus (BVDV) activity, having 50% effective concentration (EC50: based on reduction of BVDV replication-induced cell destruction) and 50% cytotoxic concentration (CC50: based on reduction of viable cell number) values of 6.2–8.4 μM and >100 μM, respectively, in Madin–Darby bovine kidney (MDBK) cells infected with BVDV. |
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