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Chloro-oxime derivatives as novel small molecule chaperone amplifiers |
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| Authors: | Yuefen Zhou Khang Vu Yongsheng Chen John Pham Thomas Brady Gang Liu Jinhua Chen Joonwoo Nam PS Murali Mohan Reddy Qingyan Au Il Sang Yoon Marie-Helene Tremblay Gary Yip Charmian Cher Bin Zhang Jack R Barber Shi Chung Ng |
| Institution: | CytRx Corporation, 3030 Bunker Hill Street, Suite 101, San Diego, CA 92109, USA |
| Abstract: | Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC50 < 10 μM). |
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