New prostaglandin derivative for glaucoma treatment |
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| Authors: | Elena Perrino Caterina Uliva Cecilia Lanzi Piero Del Soldato Emanuela Masini Anna Sparatore |
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| Institution: | 1. Istituto di Chimica Farmaceutica e Tossicologica ‘Pietro Pratesi’, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy;2. Department of Preclinical and Clinical Pharmacology, University of Florence, Viale G. Pieraccini n.6, 50139 Florence, Italy;3. CTG Pharma s.r.l., Viale Gran Sasso 17, 20131 Milan, Italy |
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| Abstract: | A hydrogen sulphide-releasing derivative of latanoprost acid (ACS 67) was synthesized and tested in vivo to evaluate its activity on reduction of intraocular pressure and tolerability. Glutathione (GSH) and cGMP content were also measured in the aqueous humour. The increased reduction of intraocular pressure, with a marked increase of GSH and cGMP and the related potential neuroprotective properties, make this compound interesting for the treatment of glaucoma. This is the first time that an application of a hydrogen sulphide-releasing molecule is reported for the treatment of ocular diseases. |
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