Synthesis of novel Gn-RH analogues using Ugi-4MCR |
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| Authors: | Armin Arabanian Mahdieh Mohammadnejad Saeed Balalaie Jürgen H Gross |
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| Institution: | 1. Peptide Chemistry Research Group, K. N. Toosi University of Technology, PO Box 15875-4416, Tehran, Iran;2. Organisch-Chemisches Institut der Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany |
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| Abstract: | An efficient method for the synthesis of some Gn-RH analogues based on Ugi reaction has been developed. Four-component reaction of N- and C-terminus peptides, aromatic aldehydes and isocyanides affords novel Gn-RH analogues derived from triptorelin and gonadorelin. All of the products were purified using preparative HPLC and the structures were assigned according to MALDI-mass spectrometry data. |
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