Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial |
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Authors: | Vandana Varshney Nripendra N Mishra Praveen K Shukla Devi P Sahu |
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Institution: | 1. Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India;2. Fermentation Technology Division, Central Drug Research Institute, Lucknow 226 001, India |
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Abstract: | A series of (5S) N-(3-{3-fluoro-4-4-(3-aryl-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide(6a–o) were synthesized and their in vitro antibacterial activity against various resistant Gram-positive and Gram-negative bacteria were evaluated. Most of the synthesized compounds showed 2 to 10 fold lower MIC values compared to linezolid against Staphylococcus aureus ATCC 25923, ATCC 70069, ATCC 29213, Bacillus cereus MTCC 430, Enterococcus faecalis MTCC439, Klebsiella pneumoniae ATCC 27736, and Streptococcus pyogens. |
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