Pseurotin A and its analogues as inhibitors of immunoglobuline E production |
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| Authors: | Minoru Ishikawa Tomohisa Ninomiya Hirotomo Akabane Nobuaki Kushida Go Tsujiuchi Makoto Ohyama Shuichi Gomi Keiko Shito Takashi Murata |
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| Institution: | Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan |
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| Abstract: | A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure–activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC50 of 0.066 μM. An immunosuppressive activity of another natural product, synerazol was also found. |
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