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1-Oxo-3-substitute-isothiochroman-4-carboxylic acid compounds: Synthesis and biological activities of FAS inhibition |
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| Authors: | Xiaokui Wang Guoming Zhao Yao Chen Xiaowei Xu Wu Zhong Lili Wang Song Li |
| Institution: | 1. Beijing Institute of Pharmacology & Toxicology, Taiping Road 27, Beijing 100850, PR China;2. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, PR China;3. Inner Mongolia Medical College, Hohht 010059, PR China |
| Abstract: | A new series 1-oxo-3-substitute-isothiochroman-4-carboxylic acid compounds have been designed and synthesized. Screening of these molecules for FAS inhibition in vitro has indicated that compounds 2c and 2d showed more effective FAS inhibition activities and higher therapeutic index than C75. |
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