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Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application |
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| Authors: | Christiane Contino-Pépin Audrey Parat Sandrine Périno Christine Lenoir Michel Vidal Hervé Galons Stephen Karlik Bernard Pucci |
| Affiliation: | 1. Université d’Avignon, Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels, 33 rue Louis Pasteur, 84000 Avignon, France;2. Université Paris Descartes, Faculté de Pharmacie and UFR Biomédicale, Laboratoire de Pharmacochimie Moléculaire et Cellulaire, Paris F-75006, France;3. Inserm U648, Paris F-75006, France;4. University of Western Ontario, Department of Medicinal Imaging, LHSC-UC, 339 Windermere Road, London, Ont., Canada N6A 5A5 |
| Abstract: | The present work deals with the synthesis of a new series of thalidomide derivatives for therapeutic applications. These compounds were evaluated in vitro on a human endothelial cell line EA.hy926 for their antiproliferative potential and in vivo on an experimental animal multiple sclerosis model called EAE as angiogenesis inhibitors. The preliminary results obtained on EAE assays seem to validate that anti-angiogenesis compounds could be promising tools for the treatment of MS. |
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