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Design,synthesis and biological evaluation of novel 2-[(2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazono]-1,3-thiazolidin-4-ones as a new class of antimicrobial agents
Authors:R Ramachandran  M Rani  S Kabilan
Institution:Department of Chemistry, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India
Abstract:New series of 2,4-diaryl-3-azabicyclo3.3.1]nonan-9-one thiosemicarbazones (916) obtained from the corresponding 2,4-diaryl-3-azabicyclo3.3.1]nonan-9-ones (18) upon cyclization with ethylbromoacetate in the presence of sodium acetate–acetic acid buffer afforded novel 2-(2,4-diaryl-3-azabicyclo3.3.1]nonan-9-ylidene)hydrazono]-1,3-thiazolidin-4-ones (1724). The synthesized compounds have been characterized by their elemental, analytical and spectral studies. Besides, the reported compounds were screened for their antibacterial and antifungal activities against a spectrum of microbial organisms. These studies proved that compounds 11/18/20/23 against Staphylococcus aureus, 19/20/24 against Salmonella typhi show maximum inhibition potency at low concentration (6.25 μg/ml) whereas 18/19 against Candida albicans and 19/20/21 against Rhizopus sp. showed beneficial antifungal activity at minimum concentration.
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