The chemoenzymatic synthesis of usnic acid |
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| Authors: | Drew J. Hawranik Kurtis S. Anderson Reesa Simmonds John. L. Sorensen |
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| Affiliation: | Department of Chemistry, University of Manitoba, Winnipeg, MB, Canada R3T 2N2 |
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| Abstract: | Usnic acid, a highly functionalized dibenzofuran, is a polyketide secondary metabolite produced by several species of lichens. Synthesis of usnic acid from commercially available starting material was accomplished in two steps. The synthesis involves the methylation of phloracetophenone followed by oxidation with horseradish peroxidase. This work will lay the foundation for further biosynthetic studies on usnic acid. |
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