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2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation |
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| Authors: | Jimmy J. Weterings Selina Khan Gerbrand J. van der Heden van Noort Cornelis J.M. Melief Herman S. Overkleeft Sjoerd H. van der Burg Ferry Ossendorp Gijsbert A. van der Marel Dmitri V. Filippov |
| Affiliation: | 1. Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands;2. Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands;3. Department of Clinical Oncology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands |
| Abstract: | The synthesis of an array of 2-azidoalkoxy substituted 7-hydro-8-oxoadenines is described. The relation of the structure of these compounds and their ability to induce maturation of dendritic cells is evaluated. |
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