1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design,synthesis and biological evaluation |
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| Authors: | Shaoyong Ke Fengyi Liu Ni Wang Qing Yang Xuhong Qian |
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| Affiliation: | 1. Shanghai Key Laboratory of Chemical Biology, Institute of Pesticides and Pharmaceuticals, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;2. Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China |
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| Abstract: | Two series of 1,3,4-oxadiazoline heterocycle derivatives were designed, synthesized and identified. Bioactivity assays showed that all synthesized compounds inhibited chitin synthesis in yeast, suggesting they might be a novel class of potential inhibitors against chitin biosynthesis. The structure–activity relationships (SAR) of these compounds are discussed. |
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