1,3,4-Oxadiazoline derivatives as novel potential inhibitors targeting chitin biosynthesis: Design,synthesis and biological evaluation |
| |
| Authors: | Shaoyong Ke Fengyi Liu Ni Wang Qing Yang Xuhong Qian |
| |
| Institution: | 1. Shanghai Key Laboratory of Chemical Biology, Institute of Pesticides and Pharmaceuticals, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;2. Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China |
| |
| Abstract: | Two series of 1,3,4-oxadiazoline heterocycle derivatives were designed, synthesized and identified. Bioactivity assays showed that all synthesized compounds inhibited chitin synthesis in yeast, suggesting they might be a novel class of potential inhibitors against chitin biosynthesis. The structure–activity relationships (SAR) of these compounds are discussed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
