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Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARδ agonists |
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| Authors: | Rui Zhang Alan DeAngelis Aihua Wang Ellen Sieber-McMaster Xun Li Ronald Russell Patricia Pelton Jun Xu Peifang Zhu Lubing Zhou Keith Demarest William V Murray Gee-Hong Kuo |
| Institution: | Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, LLC, 8 Clarke Drive, Cranbury, NJ 08512, USA |
| Abstract: | Synthesis and SAR of para-alkylthiophenoxyacetic acids is described. Achiral compounds 30, 31 and 32 were identified as potent and selective PPARδ agonists. |
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