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3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase |
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| Authors: | Robert T Hendricks Stacey R Spencer James F Blake Jay B Fell John P Fischer Peter J Stengel Vincent JP Leveque Sophie LePogam Sonal Rajyaguru Isabel Najera John A Josey Steven Swallow |
| Institution: | 1. Array BioPharma, Inc, 3200 Walnut Street, Boulder, CO 80301, USA;2. Roche Palo Alto LLC, Medicinal Chemistry, 3431 Hillview Avenue, MS: R6E-3 (R6W-120B), Palo Alto, CA 94304, USA |
| Abstract: | Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure–activity relationships are detailed, along with enzyme and cellular activity. |
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