Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1) |
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| Authors: | Tram Huynh Zhong Chen Suhong Pang Jieping Geng Tiziano Bandiera Simona Bindi Paola Vianello Fulvia Roletto Sandrine Thieffine Arturo Galvani Wayne Vaccaro Michael A Poss George L Trainor Matthew V Lorenzi Marco Gottardis Lata Jayaraman Ashok V Purandare |
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| Institution: | 1. Bristol-Myers Squibb Pharmaceutical Research and Development, Princeton, NJ 08543, United States;2. Nerviano Medical Sciences Oncology Business Unit, Viale Pasteur, 20014 Nerviano, Milan, Italy |
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| Abstract: | Design, synthesis, and SAR development led to the identification of the potent, novel, and selective pyrazole based inhibitor (7f) of Coactivator Associated Arginine Methyltransferase (CARM1). |
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