In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii |
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Authors: | Jae Yeon Kim Hyo Jin Lim Da Yeon Lee Ji Sun Kim Do Hee Kim Hwa Jin Lee Hee Doo Kim Raok Jeon Jae-Ha Ryu |
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Institution: | College of Pharmacy, Sookmyung Women’s University, 52 Hyochangwon-Gil, Yongsan-Gu, Seoul 140-742, Republic of Korea |
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Abstract: | The overproduction of nitric oxide (NO) and prostaglandin E2 (PGE2) causes neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)-yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia. The most potent compound 4 inhibited the production of NO and PGE2 and the expression of respective enzyme iNOS and COX-2 through the suppression of I-κB-α degradation and nuclear translocation of p65 subunit of NF-κB. |
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