|
|||||
|
|
Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors |
|
| Authors: | Youseung Shin Weiming Chen Jeff Habel Derek Duckett Yuan Yuan Ling Marcel Koenig Yuanjun He Tomas Vojkovsky Philip LoGrasso Theodore M Kamenecka |
| Institution: | Department of Molecular Therapeutics, and Translational Research Institute, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #A2A, Jupiter, FL 33458, United States |
| Abstract: | A novel series of c-jun N-terminal kinase (JNK) inhibitors were designed and developed from a high-throughput-screening hit. Through the optimization of the piperazine amide 1, several potent compounds were discovered. The X-ray crystal structure of 4g showed a unique binding mode different from other well known JNK3 inhibitors. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |