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Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates |
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| Authors: | Weijun Fang Yijun Cai Xiaoping Chen Rongmin Su Tong Chen Ningshao Xia Lei Li Quanli Yang Jiahuai Han Shoufa Han |
| Affiliation: | 1. Department of Chemistry, College of Chemistry and Chemical Engineering, and The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, PR China;2. College of Life Science, Xiamen University, Xiamen, Fujian 361005, PR China;3. College of Materials, Xiamen University, Xiamen, Fujian 361005, PR China;4. National Research Institute for Family Planning, Beijing 100081, PR China |
| Abstract: | Topical microbicides offer women the opportunity to protect themselves from sexual HIV transmission under their own control. A series of poly[styrene-alt-(maleic anhydride)] derivatives were prepared by amidation or hydrolysis of the anhydride moiety. The derivatives were shown to be of low cell toxicity and effectively inhibited HIV-1 infections in an in vitro cellular model. Poly[styrene-alt-(maleic acid, sodium salt)] was the most potent inhibitor, being 100-fold more potent than dextran sulfate suggesting its potential application as a new class of polyanionic microbicides. |
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