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Quaternary ammonium N,N-dichloroamines as topical,antimicrobial agents |
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| Authors: | Charles Francavilla Eddy Low Satheesh Nair Bum Kim Timothy P. Shiau Dmitri Debabov Chris Celeri Nichole Alvarez Ashley Houchin Ping Xu Ron Najafi Rakesh Jain |
| Affiliation: | NovaBay Pharmaceuticals Inc., 5980 Horton St. Suite 550, Emeryville, CA 94608, United States |
| Abstract: | A series of backbone modified and sulfonic acid replacement analogs of our topical, clinical candidate (iii) were synthesized. Their antimicrobial activities and aqueous stabilities at pH 4 and pH 7 were determined, and has led us to identify quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents. |
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