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Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase |
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| Authors: | Brian Raymer Michael Kavana Allen Price Bing Wang Lisa Corcoran Raviraj Kulathila James Groarke Theirry Mann |
| Institution: | 1. Novartis Institutes for BioMedical Research, 100 Technology Square, Cambridge, MA 02139, United States;2. Emmanuel College, 400 The Fenway, Boston, MA 02115, United States;3. Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139, United States |
| Abstract: | BODIPY-labeled Soraphen A derivative 4 was synthesized and characterized as an acetyl-CoA carboxylase (ACC) binder. Biophysical measurements indicate that the molecule binds in the biotin carboxylase domain where Soraphen A has been shown to bind. The fluorescent label of the BODIPY can be used to biophysically identify a compound that binds to the Soraphen A site of the biotin carboxylase domain versus the carboxytransferase domain of ACC. |
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