Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids |
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Authors: | James McNulty Jerald J. Nair Mohini Singh Denis J. Crankshaw Alison C. Holloway Jaume Bastida |
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Affiliation: | 1. Department of Chemistry, McMaster University, 1280 Main Street West, Hamilton, Ont., Canada L8S 4M1;2. Department of Obstetrics and Gynecology, McMaster University, 1200 Main Street West, Hamilton, Ont., Canada L8N 3Z5;3. Departament de Productes Naturals, Facultat de Farmacia, Universitat de Barcelona, Barcelona 08028, Spain |
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Abstract: | A library of natural and semi-synthetic Amaryllidaceae alkaloids was screened for cytochrome P450 3A4 (CYP3A4) inhibitory activity. Of the crinane, lycorane and galanthamine representatives examined two semi-synthetic silylated lycorane analogues, accessed via a chemoselective silylation strategy from lycorine, and the natural compound narciclasine exhibited low micromolar activities. Important pharmacological features uncovered include the lack of CYP3A4 inhibitory activity seen for galanthamine and the selective activity that is seen with narciclasine over pancratistatin. |
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