耳念珠菌的流行病学和生物学研究进展

耳念珠菌Candida auris已成为引起严重院里感染的新兴病原真菌。自2009年第一次报道以来,耳念珠菌在全球迅速传播并导致几次院内感染的暴发。与念珠菌属其他成员相比,耳念珠菌具有诸多特点,比如多重耐药、鉴别困难、死亡率高、易在医院内传播等。关于耳念珠菌的生物学和致病性研究越来越多,我们对耳念珠菌的认识也逐渐增强,本综述详细地介绍了耳念珠菌全球感染的流行病学以及该病原真菌的基本生物学特征,并对其毒力和耐药机制研究进展进行汇总,对未来关于耳念珠菌研究的前景进行了展望。

Research advances in the epidemiology and biology of Candida auris

Candida auris has emerged as a fungal pathogen leading to severe problems associated with nosocomial transmission. It has been rapidly spreading worldwide and caused several described outbreaks since the first report in 2009. Compared with other members of Candida spp., this pathogen has multiple characteristics such as multidrug resistance, difficulty in identification, high mortality and easily spread in hospital setting. Many efforts are on the way to answer the biological questions and pathogenic mechanism regarding this pathogen. In this review, the epidemiology and basic biological characteristics relevant to Candida auris are detailed, and the knowledge concerning the mechanisms of its virulence and multidrug resistance is summarized. The future research of Candida auris is prospected.