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3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors |
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| Authors: | An T. Vu Stephen T. Cohn Eugene A. Terefenko William J. Moore Puwen Zhang Paige E. Mahaney Eugene J. Trybulski Igor Goljer Rebecca Dooley Jenifer A. Bray Grace H. Johnston Jennifer Leiter Darlene C. Deecher |
| Affiliation: | 1. Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA;2. Women’s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA |
| Abstract: | A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the dopamine transporter. |
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