(1,2,3-Triazol-4-yl)benzenamines: Synthesis and activity against VEGF receptors 1 and 2 |
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| Authors: | Alexander S Kiselyov Marina Semenova Victor V Semenov |
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| Institution: | 1. deCODE, 2501 Davey Road, Woodridge, IL 60517, USA;2. Institute of Developmental Biology, RAS, 26 Vavilov Str., 119334 Moscow, Russia;3. Zelinsky Institute of Organic Chemistry, RAS, 47 Leninsky Prospect, 117913 Moscow, Russia |
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| Abstract: | Derivatives of (1,2,3-triazol-4-yl)benzenamines are described as potent and ATP-competitive inhibitors of vascular endothelial growth factor receptors I and II (VEGFR-1/2). A number of compounds exhibited VEGFR-2 and VEGFR-1 inhibitory activity comparable to that of Vatalanib? in both HTRF enzymatic and cellular assays. |
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