Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties |
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| Authors: | So-Young Kim Hyeong Beom Park Jung-Hyuck Cho Kyung Ho Yoo Chang-Hyun Oh |
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| Institution: | Life Sciences Research Division, Korea Institute of Science and Technology, PO Box 131, Cheongryang, Seoul 130-650, Republic of Korea |
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| Abstract: | The synthesis of a new series of oxazolidinones having spiro2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the oxazolidinone ring was investigated. A particular compound Ih having fluoro group showed the most potent antibacterial activity. |
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