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Discovery of 2-(α-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS |
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| Authors: | Christopher J. Burns Michael F. Harte Xianyong Bu Emmanuelle Fantino Marilena Giarrusso Max Joffe Margarita Kurek Fiona S. Legge Pasquale Razzino Stephen Su Herbert Treutlein Soo San Wan Jun Zeng Andrew F. Wilks |
| Affiliation: | Cytopia Research Pty Ltd, 576 Swan Street, Richmond, VIC. 3121, Australia |
| Abstract: | A series of 2-(α-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported. |
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