Cellular immune response and Th1/Th2 cytokines in human neurocysticercosis: lack of immune suppression. |
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| Authors: | E Medina-Escutia Z Morales-López J V Proa?o J Vazquez V Bermúdez V O Navarrete V Madrid-Marina J P Laclette D Correa |
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| Institution: | Departamento de Biotecnología, Instituto Nacional de Diagnóstico y Referencia Epidemiológicos, Secretaría de Salud, México, Col. Sto. Tomás, DF. |
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| Abstract: | Some reports have suggested that human neurocysticercosis (NCC) induces immunosuppression. To test this hypothesis, we performed a study on active cases of NCC who had not received cestocidal or immunosuppressive treatments. We examined blood counts and specific T cell markers (CD3, CD4, and CD8) by flow cytometry and found no differences between patients with NCC and healthy individuals. Both groups responded to concanavalin A (Con A), and patients with NCC responded more to a parasite crude antigen than uninfected individuals. Peripheral blood mononuclear cells were examined for interleukin (IL)-2, interferon-gamma, IL-10, and IL-4 mRNA. Regardless of infection status, more than 60% of individuals synthesized IL-2 mRNA and, less frequently, the other cytokines. These data suggest that immunosuppression does not occur in NCC patients. |
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