Binding interactions of vancomycin tracers with a bacterial cell wall peptidoglycan analogue |
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Authors: | Adamczyk M Grote J Moore J A Rege S D Yu Z |
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Institution: | Department of Chemistry, Abbott Laboratories, Abbott Park, IL 60064-6016, USA. maciej.adamczyk@abbott.com |
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Abstract: | Binding interactions between several vancomycin tracers and (N,N'-diacetyl)KDADA in solution were evaluated in a competition format using a surface plasmon resonance instrument. Tracers derivatized from the carboxy terminus or the N-vancosaminyl sugar moiety of vancomycin bind the peptide with an affinity similar to that of underivatized vancomycin. In contrast, N-methylleucyl derivatized vancomycin tracers bind the peptide with a reduced affinity relative to vancomycin. |
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