Kinetic Equations for L-Phenylalanine Production by a Hyperproducing Mutant of Escherichia Coli |
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Authors: | Nai Houn Park Peter L. Rogers |
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Affiliation: | a Cheil Sugar Co. Ltd., Ichon-Kun, Kyonggi-Do, South Koreab Department of Biotechnology, University of New South Wales, Kensington, NSW, Australia |
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Abstract: | Using a set of kinetic equations, which take account of the effect of both intra-and extracellular phosphate concentrations, the batch culture production of L-phenylalanine by a hyperproducing mutant of E. coli has been described. Good agreement has been found between the predicted results and experimental data for cell growth, glucose uptake, phosphate uptake and L-phenylalanine production for initial glucose concentrations of 16 and 26 g. L-1. The kinetic model is applicable to conditions for which no substrate inhibition or product inhibition are likely to occur. |
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Keywords: | L-phenylalanine production E. coli hyperproducing mutants kinetic model phosphate concentration |
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