A mutational analysis and molecular dynamics simulation of quinolone resistance proteins QnrA1 and QnrC from <Emphasis Type="Italic">Proteus mirabilis</Emphasis> |
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| Authors: | Qinglan Guo Jingwei Weng Xiaogang Xu Minghua Wang Xiaoying Wang Xinyu Ye Wenning Wang Minggui Wang |
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| Institution: | (1) Institute of Antibiotics, Huashan Hospital Fudan University, 12 Wulumuqi Road, Shanghai, 200040, China;(2) Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China;(3) Institute of Biomedical Sciences, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, China |
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| Abstract: | Background The first report on the transferable, plasmid-mediated quinolone-resistance determinant qnrA1 was in 1998. Since then, qnr alleles have been discovered worldwide in clinical strains of Gram-negative bacilli. Qnr proteins confer quinolone resistance,
and belong to the pentapeptide repeat protein (PRP) family. Several PRP crystal structures have been solved, but little is
known about the functional significance of their structural arrangement. |
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