Molecular genetics of polyamine synthesis in eukaryotic cells |
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Authors: | O Heby L Persson |
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Affiliation: | Department of Zoophysiology, University of Ume?, Sweden. |
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Abstract: | The polyamines putrescine, spermidine and spermine are important cellular constituents involved in the regulation of cell growth and differentiation. Their intracellular levels are regulated by a multitude of mechanisms affecting their synthesis, degradation, uptake and excretion. As a result of the application of molecular biology techniques, some of these mechanisms are presently being unravelled, and are providing a basis for the rational development of novel agents effective against proliferative disorders and various parasitic diseases. |
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