Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFκB paradigm |
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Authors: | Michael Melnick Robert D Phair Smadar A Lapidot Tina Jaskoll |
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Institution: | (1) Laboratory for Developmental Genetics, USC, Los Angeles, CA, USA;(2) Integrative Bioinformatics Inc, Los Angeles, CA, USA |
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Abstract: | Background Ectodysplasin-A appears to be a critical component of branching morphogenesis. Mutations in mouse Eda or human EDA are associated with absent or hypoplastic sweat glands, sebaceous glands, lacrimal glands, salivary glands (SMGs), mammary
glands and/or nipples, and mucous glands of the bronchial, esophageal and colonic mucosa. In this study, we utilized Eda
Ta
(Tabby) mutant mice to investigate how a marked reduction in functional Eda propagates with time through a defined genetic
subcircuit and to test the proposition that canonical NFκB signaling is sufficient to account for the differential expression
of developmentally regulated genes in the context of Eda polymorphism. |
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