Protein tyrosine phosphatases as novel targets in breast cancer therapy |
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Authors: | Caroline E Nunes-Xavier Jorge Martín-Pérez Ari Elson Rafael Pulido |
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Institution: | 1. BioCruces Health Research Institute, Hospital de Cruces, Plaza Cruces s/n, 48903 Barakaldo, Spain;2. Dpto. Biología del Cáncer, Instituto de Investigaciones Biomédicas A. Sols (CSIC/UAM), Arturo Duperier 4, 28029 Madrid, Spain;3. Department of Molecular Genetics, The Weizmann Institute of Science, 76100 Rehovot, Israel;4. Ikerbasque, Basque Foundation for Science, 48011 Bilbao, Spain |
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Abstract: | Breast cancer is linked to hyperactivation of protein tyrosine kinases (PTKs), and recent studies have unveiled that selective tyrosine dephosphorylation by protein tyrosine phosphatases (PTPs) of specific substrates, including PTKs, may activate or inactivate oncogenic pathways in human breast cancer cell growth-related processes. Here, we review the current knowledge on the involvement of PTPs in breast cancer, as major regulators of breast cancer therapy-targeted PTKs, such as HER1/EGFR, HER2/Neu, and Src. The functional interplay between PTKs and PTK-activating or -inactivating PTPs, and its implications in novel breast cancer therapies based on targeting of specific PTPs, are discussed. |
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