Synthesis and analysis of urea and carbamate prodrugs as candidates for melanocyte-directed enzyme prodrug therapy (MDEPT) |
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| Authors: | Jordan Allan M Khan Tariq H Malkin Hugh Osborn Helen M I |
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| Affiliation: | Department of Chemistry, University of Reading, Whiteknights, Reading RG6 6AD, UK. |
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| Abstract: | The suitability of 4-di(2-chloroethyl)aminoanilino-4-hydroxyphenethylaminomethanone 2 to act as a prodrug for melanocyte-directed enzyme prodrug therapy (MDEPT) is assessed. Thus its synthesis, ability to generate a cytotoxic agent upon exposure to tyrosinase, and stability within different sera are reported. A comparison is made to illustrate that the new urea prodrug 2 is a more suitable candidate for MDEPT than the corresponding carbamate prodrug 1. |
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