Turnover of T Cells in Murine Gammaherpesvirus 68-Infected Mice |
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| Authors: | Ann Marie Hamilton-Easton Jan P Christensen and Peter C Doherty |
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| Institution: | Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. |
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| Abstract: | Respiratory challenge of C57BL/6 mice with murine gammaherpesvirus 68 induces proliferation of T lymphocytes early after infection, as evidenced by incorporation of the DNA precursor bromodeoxyuridine. Using pulse-chase analysis, splenic and peripheral blood activated T lymphocytes were found to continue dividing for at least a month after the initial virus challenge. The results are in accord with the idea that T cells are stimulated for a substantial time after the acute, lytic phase of virus infection is resolved. |
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