Chronic active Epstein-Barr virus infection |
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Authors: | Kimura Hiroshi |
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Institution: | Department of Virology, Nagoya University Graduate School of Medicine 65 Turumai-cho, Showa-ku, Nagoya 466-8550, Japan. hkimura@med.nagoya-u.ac.jp |
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Abstract: | The ubiquitous Epstein-Barr virus (EBV), which establishes latency after primary infection, does not cause any symptomatic diseases as long as cellular immunity is intact. In apparently immunocompetent individuals, a chronic infection can develop, and this has been called as chronic active EBV infection (CAEBV). CAEBV is characterized by chronic or recurrent infectious mononucleosis-like symptoms, such as fever, extensive lymphadenopathy, and, hepatosplenomegaly. This disease is rare but severe with high morbidity and mortality. Recently, its pathophysiology is not an infection but a clonal expansion of EBV-infected T or natural killer NK cells. In this review, I discuss our current understanding of the pathogenesis of CAEBV and summarize its clinical features, therapies, and prognosis. |
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