Complement driven innate immune response to malaria: fuelling severe malarial diseases |
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| Authors: | Karlee L. Silver Sarah J. Higgins Chloe R. McDonald Kevin C. Kain |
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| Affiliation: | 1. Sandra A. Rotman Laboratories, McLaughlin‐Rotman Centre for Global Health, University Health Network‐Toronto General Hospital, McLaughlin Centre for Molecular, Medicine, University of Toronto, Toronto, ON, Canada.;2. Contributed equally to this work.;3. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.;4. Institute of Medical Science, University of Toronto, Toronto, ON, Canada.;5. Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University Health Network‐Toronto General Hospital, Toronto, ON, Canada. |
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| Abstract: | Severe malaria remains a major cause of global mortality. The innate immune response to infection is a key determinant of malaria severity and outcome. The complement system plays a key role in initiating and augmenting innate immune responses, including inflammation, endothelial activation, opsonization and coagulation, processes which have been implicated in malaria pathogenesis. In this review, we discuss the evidence supporting a role for excessive complement activation in the pathogenesis of severe malaria. |
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